Additionally, capsaicin increases intracellular calcium levels via the TRPV1 receptor and upregulates PGC‐1α, promoting fatty acid oxidation, mitochondrial biogenesis, and the formation of oxidative fibers, thereby enhancing exercise endurance and preventing high‐fat diet‐induced metabolic disorders (Luo et al. 2012). The gene discussed is PPARGC1A; the disease is metabolic disease.