The Fox O family is a class of transcription factors involved in many biological processes that has received increasing attention for affecting longevity, metabolism and the tumor status, and the binding of GCs to the and glucocorticoid receptor (GR) upregulates the expression of the p85a subunit of PI3K, decreases PI3K kinase activity, inhibits downstream Akt phosphorylation, increases the nuclear translocation of Fox O3 and its transcriptional activity, and upregulates the mRNA expression of Atrogin‐1 and MuRF1 (Seok et al. 2021). Here, NR3C1 is linked to neoplasm.