In patients with diabetes, IGF‐1/PI3K/Akt signaling is decreased, Fox O phosphorylation is increased, leading to its nuclear translocation, and the transcription of muscle‐specific E3 ubiquitin ligase gene‐1/muscle atrophic F‐box (Atrogin‐1/MAFbx) and muscle RING‐finger protein‐1 (MuRF1) (Shen, Li, et al. 2022) increased levels of proinflammatory cytokines, such as tumor necrosis factor α (TNF‐α) and interleukin 6 (IL‐6), activate intracellular signaling pathways and increase the transcription of many genes encoding inflammatory mediators. The gene discussed is TNF; the disease is diabetes mellitus.