However, loss of AEP significantly impaired the ability of breast cancer cells to form colonies, as shown by less colony number and smaller colony size formed by AEPKD MDA-MB-231 cells compared to that formed by WT MDA-MB-231 cells (Fig. 1G), indicating impaired survival and growth potential of individual AEPKD cancer cell under stressed conditions. The gene discussed is LGMN; the disease is cancer.