SOX2 and cancer: The upregulation of multiple lineage plasticity genes, including basal (Trp63, Krt5 and Krt14), metastasis (Snai2, Tgfb1 and L1cam), and stemness (Sox2, Mecom and Sox6) markers was induced by LKB1 loss (Fig. 4c–e), further supporting the enhanced cancer cell state plasticity by LKB1 loss.