PTEN and cancer: Additionally, we crossed Lkb1flox/flox mice with mice carrying both Tmprss2CreERT2 (a luminal cell-specific inducible CreERT2 previously established by our lab19) and floxed Pten (Tmprss2CreERT2/CreERT2; Ptenflox/flox, TP) to initiate cancer specifically in prostate luminal cells following tamoxifen administration (Tmprss2CreERT2/CreERT2; Ptenflox/flox; Lkb1flox/flox, TPL) (Supplementary information, Fig. S5d).