Notably, we discovered and further validated that LKB1 could interact with methionine adenosyltransferase 2A (MAT2A) (Supplementary information, Fig. S8d–g), a rate-limiting enzyme for the synthesis of SAM.29 Moreover, we introduced LKB1 expression in PPL cancer cells, and found that LKB1 expression significantly enhanced MAT2A activity (Supplementary information, Fig. S8h). The gene discussed is MAT2A; the disease is cancer.