STK11 and cancer: Notably, we discovered and further validated that LKB1 could interact with methionine adenosyltransferase 2A (MAT2A) (Supplementary information, Fig. S8d–g), a rate-limiting enzyme for the synthesis of SAM.29 Moreover, we introduced LKB1 expression in PPL cancer cells, and found that LKB1 expression significantly enhanced MAT2A activity (Supplementary information, Fig. S8h).