Poly(I: C) is formed by the polymerization of inosinic acid and cytidylic acid and well known as an agonist of Toll-like Receptor 3 (TLR 3) that can stimulate tumor cells to secrete immune factors, such as IL-6 and IFN-α, and then activate the tumor immune response10,11. This evidence concerns the gene IL6 and neoplasm.