Compared to other HCC patients, HBV-HCC patients had an earlier age of tumor diagnosis (median age, 55.5 years vs. 59 years, P < 0.001***), larger tumor size (> 5 cm, 40% vs. 29%, P = 0.0452*), lower cirrhosis rate (37% vs. 51%, P = 0.0158*) and higher AFP levels (> = 100 ng/mL, 47% vs. 29%, P < 0.001***). The gene discussed is AFP; the disease is hepatocellular carcinoma.