TP53 and hepatocellular carcinoma: To further characterize the genetic difference in virus-related HCCs, we investigated the rate of the most common HCC somatic mutations, including mutations in the TERT promoter (G(−124/−146)A), CTNNB1 (exon 3), and TP53 (coding sequence), in HBCV-HCC by capture-NGS, taking HBV-HCC and HCV-HCC as reference (Fig. 2).