These include pathogenic variants of G protein subunits such as the GNB3 gene in hypertension, activating GNAS variants in McCune-Albright’s syndrome [98], heterozygous inheritance of inactivating GNAS variants in AHO [101–104], and PPH resulting from heterozygous LOF GNAS variants [45]. This evidence concerns the gene GNB3 and pulmonary arterial hypertension.