[3] report two transcriptionally distinct subpopulations of CAFs in pancreatic cancer; inflammatory CAFs (iCAFs), which are a significant source of interleukin 6 (IL6), and myofibroblastic CAFs (myCAFs), with high expression of alpha smooth muscle actin (αSMA), a key role in extracellular matrix (ECM) remodelling and transforming growth factor beta (TGFβ) signalling. This evidence concerns the gene IL6 and familial pancreatic carcinoma.