Similarly, compared to CAF‐S4, CAF‐S5 also upregulates CCL4, CXCL9, CXCL10, CXCL11 and IL1RN suggesting that cytokine and chemokine transcripts are enriched in tumours with high CAF‐S1 and CAF‐S5 and low in the myCAF‐like subset CAF‐S4 (Fig. 5A). This evidence concerns the gene IL1RN and neoplasm.