CD4 and neoplasm: Interestingly, Sora significantly increased the proportions of CD4+CD25+Foxp3+ Treg cells among tumor-infiltrating leukocytes (TILs) but decreased the proportions of MHC-II+CD11c+ dendritic cells (DCs) and CD19+ B cells among TILs (Figure 2C), suggesting that Sora treatment led to the formation of an immunosuppressive TME.