In addition, tumor-associated N2 neutrophils can recruit the FoxP3+CD25+CD4+ T lymphocyte subset to increase Sora resistance in HCC cells.11, 12, 13 Moreover, myeloid-derived suppressor cells (MDSCs) facilitate CAF activation and subsequent Sora resistance by inducing FGF1 expression.14 This evidence concerns the gene CD4 and hepatocellular carcinoma.