METTL3 and neoplasm: For instance, RNA m6A methyltransferase METTL3 was upregulated by histone lactylation (H3K18) in tumor microenvironment, and moreover, METTL3 lactylation at sites of K281 and K345 enhances its ability for target RNA capturing and m6A modification deposition on target mRNAs, such as Jak1, potently inducing the immunosuppressive functions of tumor-infiltrating myeloid cells (TIMs) [11].