Histone lactylation (H3K18la) can activate mitotic checkpoint regulator TTK protein kinase (TTK) to promote the progression of pancreatic ductal adenocarcinoma (PDAC) [14], while suppression of H3K18la by circXRN2 (hsa_circ_0001134) inhibits tumor progression through activating the Hippo signaling pathway in human bladder cancer [15]. The gene discussed is TTK; the disease is pancreatic ductal adenocarcinoma.