NSUN2 and neoplasm: One recent report shows that a small ubiquitin-like modifier (SUMO)-2/3 directly interacts and stabilizes NSUN2 which is implicated in tumor progression [26].Lactic acid was observed to activate the transcription of NSUN2 through histone H3K18 lactylation (H3K18la), and also induce the lactylation of NSUN2 [27], however, whether NSUN2 lactylation regulates its methyltransferase activity and further biological function remains to be clarified.