In addition, rRNA methyltransferase 3 was linked to breast cancer as a risk factor (IVW, p=0.015, OR = 1.031, 95% CI: 1.006–1.057), while cytochrome c oxidase assembly factor 3 homolog was identified as a protective factor against breast cancer (IVW, p=0.009, OR = 1.067, 95% CI: 1.016–1.121) (Figures 3 and 4 and Table 4). This evidence concerns the gene COA3 and breast carcinoma.