The RA-obstructive CAD group exhibited significantly higher levels of cytokines, including IL-2 (P<0.001), IL-4 (P<0.001), IL-6 (P=0.037), IL-10 (P=0.001), IL-17 (P<0.001), IFN-γ (P<0.001), and TNF-α (P<0.001) (Table 3; Figure 2; Supplementary Table 2). This evidence concerns the gene TNF and rheumatoid arthritis.