SFTPD and cancer: Moreover, SP-D stands as a pivotal molecule in shaping the adaptive immune response by engaging with antigen-presenting cells such as dendritic cells, and T cells, effectively bridging the gap between innate and adaptive immunity (16, 17; 19–21), and playing a crucial role in host defence mechanisms against a myriad of pathogens, allergens, and cancer, inducing apoptosis in cancer cells and inhibiting epithelial-to-mesenchymal transition (16, 22–24).