In vivo studies involving treatment of mouse models of ABPA induced by Afu 3wcf with SP-D or rfhSP-D resulted in decreased eosinophilia and lower levels of specific IgG and IgE antibodies, along with decreased levels of IL-2, IL-4, and IL-5, and an increase in IFN-γ in the cultured spleen cells, indicating a significant shift from a pathogenic Th2 to a protective Th1 polarization of the helper T-cell immune response (100). The gene discussed is IGHE; the disease is allergic bronchopulmonary aspergillosis.