Through the analysis of key DUBGs, we found that genes such as CFTR, USP2, ITCH, ESR1, AXIN1, USP37, AKT1, OTUD6B, ZC3H12A, and SMAD3 are significantly upregulated in tumor tissues compared to normal tissues (Figures 8A, C). This evidence concerns the gene SMAD3 and neoplasm.