On the other hand, according to our results, an HV1 inhibition may also reduce the viability of polarized macrophages, mainly that of M1 cells with typical anti-tumor activities, and thereby favoring the predominant intratumoral appearance of M2-like tumor-associated macrophages, culminating in an M1-M2 imbalance, which may contribute to the immune evasion of neoplastic cells. Here, HVCN1 is linked to neoplasm.