HVCN1 and multiple sclerosis: Accordingly, in mouse disease models, genetic HV1 deficiency prevented neuronal death, brain damage and motor deficits in ischemic stroke (27, 28), carotid artery stenosis-induced white matter injury (103), demyelination in cuprizone- or lysophosphatidylcholine-induced multiple sclerosis models (29, 30), and neuronal apoptosis and pyroptosis, functional loss and pain hypersensitivity in traumatic brain and spinal cord injury models (31–34).