MYC and leukemia: Thus, it has been shown that in leukemias (both human and mouse) MYC oncogene binds to the distal enhancer regions of the CD47 promoter to regulate its activity (16), while HIF-1α and NFκB transcription factors have been implicated in the regulation of CD47 promoter in breast, cervical, and non-small lung carcinoma cells (17–19).