CTLA4 and hyperthyroidism: However, the random distribution of genetic variation andgenotype at birth have determined the priority of the MR analysis [38, 39].Although GD shared similar clinical and diagnostic featureswith other types of hyperthyroidism, a genome-wide linkage andassociation study have identified significant and unique effects on GDsusceptibility from gene variants such as HLA, CTLA4, andPTPN22 [40].