PXDN and pulmonary arterial hypertension: Magnesium lithospermate B administrationinhibited cardiomyocyte hypertrophy and decreased the expression of NADPH oxidase(NOX) (especially NOX2 and NOX4) and VPO1, which effectively preventedhypoxia-induced RV remodeling process in PAH rats by blocking the activation ofNOX/VPO1 and ERK signaling pathways [66].