STAT3 and pulmonary arterial hypertension: In in vitro experiments, IL-17 inhibitedcardiomyocyte viability and triggered the apoptotic process of cardiomyocytesthrough the STAT3 signaling pathway, exacerbating right ventricular remodeling,regardless of whether they were under normoxic or hypoxic conditions [59].Magnolol effectively alleviated the hypoxia-induced hypertrophy and fibrosisprocess in the RV of PAH rats and inhibited right ventricular remodeling byblocking the JAK2/STAT3 signaling pathway [60].