Studies have confirmed that the Janus kinase 2 (JAK2)/signal transduction andactivation of transcription 3 (STAT3) signaling pathway plays a key role inregulating the expression of transforming growth factor II, collagen type I alpha1 (COL1A1), and myosin heavy chain 7 (Myh7), which in turn participates in AngII-induced myocardial hypertrophy and fibrosis, and ultimately promotes thedevelopment of cardiac remodeling [18]. The gene discussed is JAK2; the disease is cardiac hypertrophy.