Huang and coworkers [68]demonstrated that during the transition from compensatory hypertrophy tocongestive heart failure in rats, the MHC was switched from α-MHC toβ-MHC, and this switch plays an important role in cardiac dysfunction.Our study indicates that the structural switch from α-MHC toβ-MHC in cirrhosis also plays an essential role in CCM [31]. This evidence concerns the gene HLA-C and Cirrhosis.