TNF and diabetes mellitus: They showedthat both CB1 receptors and endocannabinoid anandamide levels are increased inhearts with diabetic cardiomyopathy, and other cardiac contractile suppressorssuch as reactive oxygen species (ROS), tumor necrosis factor-alpha (TNFα) and interleukin-1β are increased.Pharmacological inhibition or genetic deletion of CB1 receptors decreased thelevels of cardiac contractile suppressors and improved diabetes-induced cardiacdysfunction.