INS and Hyperglycemia: Combined with preprandial insulin, it ↓postprandial hyperglycemia by ↓hyperglucagonemia & ↓gastric emptying. Pre-meal pramlintide with insulin also ↓ glycated haemoglobin (HbA1c) by 0.3–0.7% & ↓body weight by 0.4–1.4 kg.