It indicated that GRB7 expression was significantly elevated in BRCA, CHOL, COAD, KIRP, LIHC, LUAD, and THCA (p<1×10-13), CESC, STAD (p<1×10-11), BLCA, ESCA, head and neck squamous cell carcinoma (HNSC), READ, UCEC (p<1×10-9), and LUSC (p<1×10-5). Here, GRB7 is linked to head and neck squamous cell carcinoma.