In our opinion, as it is difficult to differentiate syndromic from non-syndromic cardiomyopathy in newborns and infants, genetic analysis should not be limited to a targeted panel of genes associated with non-syndromic cardiomyopathy, but should also include a broad screening of known genes for syndromic cardiomyopathy, including ALMS1. Here, ALMS1 is linked to cardiomyopathy.