Anti-VEGF: anti-vascular endothelial growth factor; CI-DME: center-involved diabetic macular edema; NCI­ DME: noncenter-involved diabetic macular edema; NPDR: non-proliferative diabetic retinopathy; PDR: proliferative diabetic retinopathy. This evidence concerns the gene VEGFA and proliferative diabetic retinopathy.