TET2 and Stroke: Concurrently, there was an enrichment of gene sets involved in synaptic function and repair, such as “Chemical Synaptic Transmission,” “Modulation of Chemical Synaptic Transmission,” “Anterograde Trans-Synaptic Signaling,” “Nervous System Development” and “Axonogenesis.” From these data it could be hypothesized that Tet2-mediated CH accelerates inflammation resolution after a stroke, facilitating the restoration of synaptic function and improving neurological outcomes.