In addition, cisplatin-loaded poly (l-glutamic acid)-graft-methoxy poly (ethylene glycol) nanoparticles (CDDP-NPs) enhance antitumor CD8+ T cell responses in tumor-bearing mice by maintaining persistent tumor MHC-I overexpression, facilitating MHC-I-TCR interaction, and activating TCR signaling. This evidence concerns the gene CD8A and neoplasm.