Similarly, amphiphilic block copolymers, TfR-T12-PEG-PLGA and TATH7-PEG-PLGA, self-assemble into nanocomposite micelles to co-deliver PTX and imiquimod, targeting glioma via TfR-mediated Blood-Brain Barrier penetration and pH-sensitive mechanisms. Here, TFRC is linked to glioma.