CAT and Hyperglycemia: Hyperglycemia triggers the overproduction of ROS, which in turn, through several pathways, could exert its detrimental effects, such as lipid peroxidation and the production of highly reactive aldehydes such as malondialdehyde (MDA), destruction of antioxidant defense systems including glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) [10, 11].