As a regulator of cardiovascular, gastrointestinal, reproductive, and immune systems, CRH plays a variety of biological effects in the cardiovascular system, such as vasodilation, positive inotropic and inotropic effects, and cardiac protection against ischemia-reperfusion injury, so it may be a potential therapeutic target for CAD, congestive heart failure, and hypertension [33]. This evidence concerns the gene CRH and hypertensive disorder.