In KDIGO (Kidney Disease: Improving Global Outcomes) guideline, CKD was defined as a persistent GFR < 60 mL/min/1.73 m2 (GFR categories G3a-G5) or one marker of kidney damage (eg, a urine albumin-to-creatinine ratio (UACR) ≥ 30 mg/g) for > 3 months [10, 11]. This evidence concerns the gene ALB and chronic kidney disease.