These results are consistent with the experiment that Res inhibits liver fibrosis by regulating the NLRP3/caspase-1/IL-1β signaling pathway [35], and the intervention of SD rat high-fat model reduces the expression of NF-κB p65, IL-1β, IL-18, NLRP3, and other proteins [29]. The gene discussed is IL18; the disease is Hepatic fibrosis.