The top 10 pathways were morphine addiction, cell cycle, thyroid hormone signaling pathway, neuroactive ligand–receptor interaction, prolactin signaling pathway, viral carcinogenesis, Alzheimer disease, chronic myeloid leukemia, lipid and atherosclerosis, and retrograde endocannabinoid signaling (Figure 4(d)). This evidence concerns the gene PRL and early-onset autosomal dominant Alzheimer disease.