It is worth mentioning that a study recently published by Meersch et al. [29] showed that high-dose RIPC could stimulate increases in tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 increases in patients refractory to low-dose RIPC and decrease the incidence of AKI after cardiac surgery. This evidence concerns the gene IGFBP7 and acute kidney injury.