In the context of cardiac hypertrophy, knocking down DJ-1 can significantly inhibit cardiomyocyte autophagy and enhance TORC 1 and mTORC2 phosphorylation, while overexpressing DJ-1 can alleviate phenylephrine-induced cardiac hypertrophy and promote autophagy within cardiomyocytes [28]. The gene discussed is PARK7; the disease is cardiac hypertrophy.