IL6 and cancer: Moreover, as shown in the crosstalk map, AF and cancers share various interlinked inflammatory and immune pathways (e.g., interleukin-2 family signaling, interleukin-6 signaling, interleukin-12 family signaling, and Th1 and Th2 cell differentiation), which is consistent with previous studies indicating that AF might represent an inflammatory complication of malignancies [37–39].