When we restricted the analysis to the 24 robust and specific hidden genes (novel genes potentially associated with AF), six genes were demonstrated to be differentially expressed in the patients with AF and sinus rhythm, namely, APLP1, CREB1, CREBBP, PRMT1, IRAK1, and PLXND1 (Table 1). The gene discussed is CREBBP; the disease is atrial fibrillation.