In the pathway analysis, inflammatory-immune disease (e.g., IBD, influenza, and RA) and the related pathways (e.g., the IL-17 signaling pathway, the NOD-like receptor signaling pathway, interleukin-4 and interleukin-13 signaling, and signaling by interleukins) were enriched among the AFgenes. The gene discussed is IL4; the disease is rheumatoid arthritis.