BRCA1 and breast cancer: evaluated 1,663 Brazilian BC patients, who underwent germline multi-gene panels covering from 20 to 38 genes, which showed a 17.5% rate of deleterious variants in HMP genes, including 10.1% in BRCA1/2, 13.4% in high-penetrance (HP), and 4.1% in moderate-penetrance (MP) genes.