Furthermore, in a clinical study, the researchers stimulated biopsied intestinal mucosa of PI-IBS and healthy people with Akk and found that the release of anti-inflammatory cytokine IL-13 in PI-IBS patients increased significantly after Akk stimulation, which was higher than that in the healthy control group, further explaining the anti-inflammatory effect of Akk in IBS[47]. The gene discussed is IL13; the disease is irritable bowel syndrome.