TNFRSF11B and acromegaly: The assessment of interactions between SCL and OPG/RANK-L system in acromegaly continues to be challenging due to many factors influencing levels of SCL, OPG, and RANK-L, however, it is worth noting that a more detailed understanding of the pathomechanism of bone complications in acromegaly may contribute to better diagnostic and therapeutic management and improvement of the quality of life in acromegaly patients.