CD4 and psoriasis: Interestingly, although monocyte-2, considered as monocyte-myeloid derived suppressive cell (89), mainly by its capacity of differentiate naïve CD4+ T cells to CD4+, CD25+, Foxp3+ regulatory T-cell (Treg) (90), in Psoriasis, the induced-Treg differentiated by monocytes-2 showed a deficient suppressive activity (91).