Startingfrom proteins mainly associated with lipid transport andso important in cholesterol metabolism, we observed that many apolipoproteinsidentified were negatively regulated, as well as the negative regulationof haptoglobin and hemopexin, proteins strongly involved in the activityof apolipoproteins.43 The decrease in allof these proteins shows that a possible increase in cholesterol andtriglycerides correlates with an increase in liver damage seen inhigh-severity hepatitis and nonalcoholic fatty liver disease.44,45. This evidence concerns the gene HP and hepatitis A virus infection.