The regulation ofimportant pathways related to NF-kB is definedin autoimmune diseases, as the increase in its signaling contributesto autoimmunity and chronic inflammatory processes by activating Tcells.32,33 Thus, there is the possibility of TRAF3in the direct activation of immune complexes by cytokine signaling,lymphocyte-mediated immune response, and consequent increase in hepatichyperimmune activity. Here, NFKB1 is linked to autoimmune disease.