The Gremlin-1 protein (GREM1) was found only in the sample positivefor non-HepA-E hepatitis in all replicates analyzed and with upregulation.The process of liver fibrosis is the chronic stage and the main aggravatingfactor of the most diverse types of hepatopathologies, including hepatitis.The upregulation of Gremlin-1 demonstrated its importance in the reductionof hepatoprotection as well as in the possible induction of liverfibrosis in some diseases that affect the liver due to its increasedexpression. This evidence concerns the gene GREM1 and hepatitis A virus infection.