The inferior temporal lobe is an important region in the progression of Alzheimer’s disease, considered to mark the spread of tau pathology outside of medial temporal lobe.47,48 Thus these findings suggest that tau in Aβ+ LBD participants may follow a spatial pattern similar to early stages of Alzheimer’s disease, despite this group having levels of 18F-PI-2620 considerably lower than the Alzheimer’s disease participants included in the present study. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.