The proteins in cluster-2 (C-2) were also mostly negatively correlated with NOP score and were significantly associated with Alzheimer disease (rno05010, FDR q = 1.94E−12), MAPK6/MAPK4 signaling (rno5687128, FDR q = 9.07E−17), and NF-kB signaling (rno5676590, FDR q = 9.07E−17; rno5607761, FDR q = 9.07E−17), and NF-kB activation (rno2871837, FDR q = 1.42E−15). Here, MAPK4 is linked to early-onset autosomal dominant Alzheimer disease.