We previously reported that IgM anti-PC could be a protection marker in CVD including both stroke and myocardial infarction (MI), atherosclerosis progress, and also mortality after MI,1,6,8,9 as well as in other chronic inflammatory and/or autoimmune conditions, including systemic lupus erythematosus (SLE) and rheumatoid arthritis.1 The gene discussed is CD40LG; the disease is atherosclerosis.