As shown in Table 2, we observed significant associations with lower risk of composite CVD and IHD comparing highest quintile of IgM anti-PC with lowest; multivariable-adjusted HRs: 0.42 (95% CI: 0.21-0.84; P trend = 0.06) for composite CVD and 0.35 (95% CI: 0.14-0.84; P trend = 0.05) for IHD. The gene discussed is CD40LG; the disease is myocardial ischemia.