This pleotropic effect is particularly advantageous for catecholaminergic polymorphic ventricular tachycardia (CPVT), where a gain-of-function mutation of the RyR channels results in increased calcium influx and increasing cell excitability (Kryshtal et al., 2021). Here, RYR2 is linked to catecholaminergic polymorphic ventricular tachycardia.