Currently, hypertension, HFSR, and fatigue are attributed to the inhibition of several tyrosine kinases, whereas haemorrhage, proteinuria, wound complications, and perforation are more closely related to the inhibition of the VEGF pathway (Roodhart et al., 2008; Hartmann et al., 2009; Keating and Santoro, 2009). Here, VEGFA is linked to Hypertension.