Additionally, Liu et al. (Li et al., 2023b) revealed that p53 G245S mutation enhances ESCC proliferation and metastasis through hnRNPA2B1-ADP-ribosylation factor GTPase-activating protein 1 (AGAP1) mediated exosome formation. This evidence concerns the gene HNRNPA2B1 and esophageal squamous cell carcinoma.