Additionally, Liu et al. (Li et al., 2023b) revealed that p53 G245S mutation enhances ESCC proliferation and metastasis through hnRNPA2B1-ADP-ribosylation factor GTPase-activating protein 1 (AGAP1) mediated exosome formation. The gene discussed is AGAP1; the disease is esophageal squamous cell carcinoma.