In recent years, studies have shown that obesity is linked to a low-grade inflammatory process, marked by elevated levels of pro-inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and acute-phase proteins such as C-reactive protein (CRP) (Rodríguez-Hernández et al., 2013). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.