For example, Legionella pneumophila infection of mice induced IL-1, IL-12, and IFN-γ pro-inflammatory cytokines and Th1 immune response, whereas THC treatment prior to the infection suppressed immunity and early-stage IFN-γ, IL-12, and IL-12 receptor β2 responses during L. pneumophila infection [77]. This evidence concerns the gene IFNG and infection.