In multivariate analysis, after adjusting for age, smoking, diabetes, hypertension, hyperlipidemia, anti-CCP autoantibodies, and disease activity, the Hp 2-2 genotype remained independently associated with CVD (adjusted matched OR 1.13, 95% CI 1.01–1.27, p = 0.033) (Table 3). This evidence concerns the gene HP and diabetes mellitus.