These finding imply that OGG1 expression might be adversely related to cancer development and progression, potentially due to the activation of oncogenes or inactivation of tumor suppressor genes, which could be regulated by OGG1 in an epigenetic-like manner (see Sect. “The potential role of 8-oxoGua in tumorigenesis may arise from its epigenetic-like properties.”). Here, OGG1 is linked to cancer.