Immunohistochemical analysis of tumor tissues further confirmed that depletion of Ephexin1 combined with IWR1-endo treatment led to reduced levels of Ki67 and β-catenin (Fig. 6f) and decreased expression of Wnt/β-catenin target genes and Wnt ligand genes (Fig. 6g and Supplementary Fig. 14d) compared with those in the controls. This evidence concerns the gene MKI67 and neoplasm.