YTHDC1 and cancer: Through the integration of RNA-seq, RIP-seq and published m6A datasets, we identified a subset of direct targets of YTHDC1, including SMAD6. Notably, SMAD6 transcripts exhibited reduced colocalization with YTHDC1 in UCB tissues compared with adjacent normal tissues, indicating that the YTHDC1–SMAD6 interaction was disrupted during cancer progression.