Cardiomyocytes develop from the mesoderm regulated by BMP and WNT signaling.[24] Brain tissue from FCD patients showed high levels of BMP4 in malformed neurons, such as dysmorphic neurons, giant neurons, balloon cells, giant cells, and reactive astrocytes.[25] In our data, we also found that high levels of BMP and WNT signaling were maintained in dorsal forebrain organoids and patient cortical tissue. Here, BMP4 is linked to fleck corneal dystrophy.